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In AD patients topographical disorientation, the inability to orient oneself in one's surroundings, is an early symptom of AD and often causes patients to wander and get lost 43

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Ninety minutes post-injection, animals were anesthetized and perfused for c-Fos immunostaining, a marker of neuronal activation [2]

Ylnen S, Siitonen A, Nalls MA, Ylikotila P, Autere J, Eerola-Rautio J, Gibbs R, Hiltunen M, Tienari PJ, Soininen H et al (2017) Genetic risk factors in Finnish patients with Parkinsons disease

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Melatonin: It is known to reverse oxidative damage to an extent and help the body sync with its natural circadian rhythm