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Phytochemicals as Nrf2 inducers Despite the clinical success of some Nrf2 activators, their broad electrophilic reactivity with proteins containing reactive cysteine residues leads to significant off-target effects and challenges in achieving precise therapeutic outcomes, thereby presenting substantial barriers to clinical translation

3.2 Therapeutic potential via paracrine mechanisms The therapeutic effects of MSCs are primarily mediated through their paracrine activity, which involves the secretion of bioactive factorssuch as growth factors, chemokines, cytokines, and EVsto modulate the local microenvironment (Pittenger et al., 2019

Am J Clin Nutr 2021;113(4):821831

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[6-[[(4-Bromo-2-methylphenyl)amino]carbonyl]-2-benzothiazolyl]carbamic acid, 1,1-dimethylethyl ester

Inflammation, which is strongly related to oxidative stress, can be brought on by a chronic adrenal hormone imbalance