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The presence of elevated tissue TPAH levels led the authors to conclude that the injuries observed in 2011 may have resulted from an acute event (Silva et al., 2016)

Our study suggests USWE as a potentially transformative tool for an objective assessment of variations in regional elastic modulus, thereby enabling (i) biomechanical phenotyping for patient stratification, (ii) data-driven therapeutic selection, and (iii) quantitative monitoring of tissue remodeling and also addressing the fundamental limitations of current symptom-based management approaches