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Disruption of metal transport proteins can lead to both toxic accumulation and essential deficiencies (Zheng and Monnot, 2012).Chelation therapies and metal modulating nutraceuticals are currently under investigation as potential therapeutic options in AD (Sensi et al., 2018)

Lon is upregulated in response to ROS and may interact with other mitochondrial proteins, such as NADH Ubiquinone Oxidoreductase Core Subunit S8 (NDFUS8) and/or Pyrroline-5-carboxylate reductase 1 (PYCR1) (Kuo et al

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Glob Vet 9:376383 Oguche EE, Ibegbu AO, Hamman WO (2016) The effect of Rauvlfia vomitoria on mercury-induced changes on the histology of the hippocampus of adult wistar rats