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Metreleptin Metreleptin (MYALEPT) is an injectable human recombinant leptin analogue approved in Japan for metabolic disorders including lipodystrophy and in USA as first-line treatment for non-HIV related forms of generalized lipodystrophy (leptin deficiency, congenital/acquired lipodystrophy) (22)

Proline is considered one of the major adaptive mechanisms of the induced stress by heavy metal (Zengin and Munzuroglu, 2005)