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This connection was also confirmed by Zhu et al.s (2018) group who found that upregulation of RIPK3 triggers ER stress which subsequently increased Ca 2+ overload and xanthine oxidase activity leading to overproduction of ROS, all of which was reduced by RIPK3 deletion

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Intranasal deferoxamine reverses iron-induced memory deficits and inhibits amyloidogenic app processing in a transgenic mouse model of Alzheimer's disease

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