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Treatment consists of removing the foreign object and providing supportive care

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ROS accumulation as a result of endogenous antioxidant inhibition causes damage to biomolecules such as DNA, proteins, and lipid peroxidation, leading to the formation of MDA (Su et al

In this context, the observed reduction in RONS levels, suppression of iNOS expression, and activation of the Nrf2/ARE pathway suggests that VACV actively promotes an antioxidant state early during infection