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in the termination stage, the antioxidant system, including GPX4, reduces lipid peroxides to non-toxic lipid alcohols (LOH), interrupting the chain reaction (Wei et al., 2023)
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Mettl3 mediated ferroptosis in chondrocytes and promoted pain in koa via hmgb1 M6a modification
"Steve" Ruben Distinguished Chair, The University of Texas MD Anderson Cancer Center, Houston, Texas Professor, Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX Education & Training Degree-Granting Education Postgraduate Training Licenses & Certifications Experience & Service Faculty Academic Appointments Del and Dennis McCarthy Distinguished Professor, Gastroenterology - Research, The University of Texas MD Anderson Cancer Center, Houston, TX, 2019 - 2025 Associate Professor, Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2012 - 2019 Assistant Professor, Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2006 - 2012 Administrative Appointments/Responsibilities Genetics and Gene Regulation, Program Leader, The University of Texas MD Anderson Cancer Center, Houston, Texas, 2025 - Present Associate Vice President for Translational Integration, The University of Texas MD Anderson Cancer Center, Houston, TX, 2023 - Present TRACTION Medical Director, Therapeutics Discovery Division, The University of Texas MD Anderson Cancer Center, Houston, TX, 2022 - Present Deputy Chair for Translational Research, Gastrointestinal (GI) Medical Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - Present GI Program, Program Leader, Cancer Center Support Grant, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - Present Co-Director, Graduate Program in Cancer Biology, Graduate School of Biological Sciences, The University of Texas MD Anderson Cancer Center, Houston, TX, 2016 - 2022 Other Professional Positions Chair, NCI Colon Task Force, Bethesda, 2017 - 2023 NRG Vice Chair, Colon Cancer, NSABP/RTOG/GOG (NRG) Cooperative Group,, Philadelphia, 2015 - Present Senior Editor, Clinical Cancer Research AACR, Bethesda, 2014 - Present Member, NCI Gastrointestinal Steering Committee, Bethesda, MD, 2014 - 2017 Co-Chair, Southwest Oncology Group (SWOG) Translational Sciences GI Sub-Committee, Ann Arbor, MI, 2014 - 2016 Member, SWOG - Southwest Oncology Group, Ann Arbor, MI, 2012 - Present Co-Chair, NCI Colon Task Force, Genomics Subcommittee, Bethesda, MD, 2012 - 2016 Regular Member Graduate Faculty, Graduate School of Biomedical Sciences, University of Texas Health Science Center, Houston, TX, 2010 - Present Extramural Institutional Committee Activities Member, MD Anderson/UT Austin Accelerator Scientific Review Board, The University of Texas MD Anderson Cancer Center, 2026 - Present Voting Member, Genomic Testing Executive (GTEC), The University of Texas MD Anderson Cancer Center, 2025 - Present Member, Joint Steering Committee, The University of Texas MD Anderson Cancer Center, 2025 - Present Member, Joint Steering Committee Member, The University of Texas MD Anderson Cancer Center, 2024 - Present Member, Taiho Alliance (JSC), The University of Texas MD Anderson Cancer Center, 2024 - Present Member, External Advisory Board, University of Arizona Comprehensive Cancer, 2023 - Present Member, J.P
