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Richardson TG, Leyden GM, Wang Q, et al

Ragulator is anchored by lipidation of its LAMTOR1 subunit, and the lipid anchor is connected to the folded core of Ragulator by a 45-residue N-terminal disordered region 23,24,45,46,47 , with an estimated end-to-end length of ~47 on average and an extended length 48 of ~100 (Extended Data Fig

On the one hand, DSIP may clear excessive reactive oxygen species in cells through its antioxidant effect, protecting cells from oxidative damage

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Fukai T, Ushio-Fukai M