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The profound fatigue, the unpredictable crashes, and the cognitive fog are not just "in your head"they are the result of measurable, biological dysfunctions, deeply rooted in mitochondrial impairment and systemic oxidative stress

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204,207 These results raise the possibility that RNAP II and mtRNAPs might function as both sensors and executors, which sense NAD + /NADH ratios and induce the NAD + capping to regulate the gene expression, leading to the crosstalk between cellular NAD + metabolism and transcriptional activity

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10.1016/j.trac.2023.117248 193 QiaoX.BaoL.LiuG.CuiX