Mitochondrial dysfunction and mitophagy in Parkinsons: from familial to sporadic disease
The Dementia Risk Index functional Test (DRIfT) measures five key biomarkers strongly linked to cognitive function, brain ageing and dementia risk: Omega-3 essential fats that help build and protect brain cells Vitamin D supports brain, immune and cognitive health Homocysteine a marker linked to B vitamin status and increased dementia risk when elevated HbA1c measures average blood sugar balance over time Glutathione Index reflects antioxidant protection and oxidative stress in the brain and body Together, these create your personalised DRIfT score, helping identify areas that may need attention to support long-term brain health
in: PubMed | Google Scholar | 1 Department of Pathology, Microbiology, and Immunology, 2 Division of Gastroenterology, Hepatology, and Nutrition, Department of Medicine, and 3 Center for Mucosal Inflammation and Cancer, Vanderbilt University Medical Center, Nashville, Tennessee, USA
Bad Genes and Bad Amyloids Offer the Best Protection By far the greatest risk factor of Alzheimers disease, but also implicated in some forms of Parkinsons disease (Tsuang et al., 2013
A 2023 meta-analysis of these trials concluded that probiotics (usually multi-strain combinations of Lactobacillus and Bifidobacterium ) led to a significant reduction in pro-inflammatory cytokines (like TNF- and IL-6) and a slight improvement in patients Expanded Disability Status Scale (EDSS) scores [201]
Further, in certain embodiments, the antibody construct of the invention may be formulated as a lyophilizate using appropriate excipients such as sucrose
