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Closer examination of the relationship between isotopologue similarity and metabolic reaction steps revealed that the isotopologue similarity score decreased as steps of reactions increased, either in [U- 13 C]-glutamine or [U- 13 C]-glucose labeling experiments (Supplementary Fig

10.3390/antiox11101958 76

Why this matters This approach supports the bodys ability to produce and regulate NAD internally, rather than delivering NAD itselfallowing physiologic control over how much NAD is generated based on cellular demand

Nrf2 comprises seven Neh structural domains, each imbued with distinct functionalities

J Biol Chem 290:67056713

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