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The predominant pre-clinical models of demyelination are in vivo animal models such as the experimental autoimmune encephalomyelitis (EAE) or cuprizone (CPZ) mouse model (Torre-Fuentes et al., 2020)

Numbness in the feet and limbs may make it hard for a person to walk without support

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Physician Assistants : Often provide care in collaboration with physicians and can document and bill for this diagnosis

doi: 10.1080/14787210.2017.1364992 291 NewmanD

The reagents for the next peptide bond addition are then added, and the purification steps repeated