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In addition, long-term medication may lead to drug resistance and hampers the efficacy of ACDs

reported that cyst(e)ine promotes GPX4 protein synthesis by activating mTORC1 signaling, thus enhancing ferroptosis resistance to RSL3 [21]

The medication is often taken orally but is also available as a Toradol shot

As a new chemical entity, the pharmacodynamics and pharmacokinetics of the prodrug cannot be simply speculated by the characteristics of the parent drug

152 Moreover, the decreased permeability of the brain-blood barrier (BBB) to leptin and impaired leptin signal transduction in neurons will lead to leptin resistance in obesity