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Biochem 145 , 5164 (2015)

Consequently, the findings of this study may provide a rationale for increasing the efficacy of tamoxifen treatment through drug combinations that independently increase ROS and synergize to: a) better target P-gp expressing cells

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Similarly, in renal cell carcinoma, berberine treatment increases ROS levels and apoptosis rates, accompanied by the protein upregulation of Bax, Bad, Bak, Cytochrome, the downregulation of Bcl-2c and activating Caspase-3, and Caspase-9 [219]