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In this review, we delineate the regulation of metabolic pathways for BCAAs at the tissue-specific level and summarize recent findings regarding the role of BCAAs in the control of metabolic health and disease in mammals

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To assess whether these molecular changes translate into tumor growth inhibition, we subcutaneously grafted LNCaP and LNCaP APIPC cells into NOD scid gamma (NOD.Cg-Prkdc scid Il2rg tm1Wjl /SzJ) mice (non-castrated for LNCaP and castrated for LNCaP APIPC )

despite only modest gains in intrinsic potency, it achieves effective concentrations in vivo and delays tumor growth in xenograft models (12)