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Studies have shown that 1,25(OH)D enhances intercellular adhesion among keratinocytes by upregulating E-cadherin expression and inhibiting -catenin nuclear translocation, thereby stabilizing adherens junction complexes and reinforcing the integrity of tight junctions in the epidermis [222]

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Complement and inflammasome overactivation mediates paroxysmal nocturnal hemoglobinuria with autoinflammation

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This approach will tend to result in weight-adjusted doses that are larger for women compared with men and smaller for older and obese patients