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Various pathogenic mechanisms and critical components have been reported, despite the fact that the origin is unknown, such as protein aggregation, iron buildup, mitochondrial dysfunction, neuroinflammation and oxidative stress

All distinct e-GSTs from humans, Bos taurus (cow), Sus scrofa (pig), Capra hircus (goat), Equus caballus (horse), Equus asinus (donkey) and Ovis aries (sheep), show very similar amino acid sequences, identical kinetics and stability properties

Its one of the most common and dangerous side effects of long-term NSAID use

Proc Natl Acad Sci U S A , 111 (7), 24472452

After incubation, samples were used in the immunostaining or other assays