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Homocysteine-NMDA receptor-mediated activation of extracellular signal-regulated kinase leads to neuronal cell death

Patients with Known or Suspected Mitochondrial Disease Valproic acid is contraindicated in patients known to have mitochondrial disorders caused by POLG mutations and children under two years of age who are clinically suspected of having a mitochondrial disorder [seeContraindications (4)]

Now, the form of acupuncture that they explored was one that's commonly in use called electroacupuncture

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Carnitine-Acylcarnitine Translocase Deficiency