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The peroxisome proliferator-activated receptor-gamma (PPAR) coactivator-1alpha (PGC-1) is known as a core regulator of the mitochondrial biogenesis ( 2 O 2 ), have been confirmed to act as signaling molecules, regulating the transcription of genes and affecting protein modification in ex vivo experiments ( 2 O 2 to lung fibroblasts can cause an increase in the expression of NRF-1 ( 2 O 2 to mouse embryonic cells can increase the levels of PGC-1 and PGC-1 mRNA, which may be necessary for motion-induced mitochondrial biogenesis ( Supplementation of antioxidants directly reduces the total amount of ROS in skeletal muscle, including H 2 O 2 as a signaling molecule, which could blunt the exercise-induced mitochondrial biogenesis signal

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Side effects are rare but can include mild discomfort or allergic reactions

10.1186/s12933-020-01068-7 101 LaiteerapongN.HuangE