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[38] Studies with oral dosing of glutathione in healthy human volunteers have shown no increase in cysteine, glutathione, or glutamate levels after a 3gram dose, [39] leading the authors to conclude: "It is not possible to increase glutathione to a clinically beneficial extent by the oral administration of a single dose of 3 grams of glutathione." Using the rate limiting amino acid L-cysteine to increase glutathione production may be inadvisable since it appears to autooxidize rapidly in the bloodstream and increase free radical load

doi: 10.1016/j.neurobiolaging.2011.02.003 60 LiX.SunX.CarmelietP