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Mock) were identified according to two criteria: (1) fold change and (2) statistical significance determined by unpaired Students t -test followed by BenjaminiHochberg correction

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Kynurenine is subsequently converted to NAD + in a chain of reactions with the rate-limiting step by quinolinic phosphoribosyltransferase (QPRT), which converts quinolinic acid into nicotinic acid mononucleotide (NAMN) 26 , finally entering the PreissHandler pathway