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placebo over 68 weeks

Oncogene 4 , 13831388 (1989)

She has worked with some of the senior most doctors in the largest government and private hospitals for more than 15 years

In addition to a lack of high-quality evidence of benefit in RLS sufferers, benzodiazepines have well-known side effects that limit their use, including daytime sedation, cognitive impairment, instability and falls, tolerance and dependence, depression, and respiratory failure, particularly in older adults (Walters 2024)

Such non-specific interactions reduce the concentration of free drug, diminish effective accumulation in target tissues, and can accelerate metabolic clearance [65, 72,73,74]