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Nutrients such as vitamin B12, folate, choline, betaine, and other amino acids interact with this cycle, affecting overall metabolic balance

Results Deletion of PRX3 is tumor suppressive To investigate the functional role of PRX3 expression in supporting mesothelioma growth we established CRISPR/Cas9 knockout of PRX3 in the human biphasic mesothelioma cell line H-MESO-1, generating two clones, H-Meso PRX3-1 , a compound heterozygote deletion, and H-Meso PRX3-2 , a homozygote deletion (referred to as PRX3 KO clones) (Fig

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