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429,430,431,432,433 The mechanism of enhanced glycolysis involves the activation of pyruvate kinase isoenzyme M2 (PKM2), which triggers downstream inflammatory factors in a hypoxia-inducible factor 1 (HIF-1)-dependent manner

The SDS requires further investigation with ethnically diverse samples and different age groups and settings, establishing its test-retest stability, invariance across different cultures, and its predictive validity, by exploring its relationship with other relevant psychological constructs, such as anxiety and mood disorders or attention deficit hyperactivity disorder (ADHD) (272), especially in clinical samples by identifying how the frequency and compulsiveness of smartphone use and the impact of this cognitive-emotive construct may contribute to the deterioration or alleviation of symptoms of various disorders (273)

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ECAESDUSM 20123011) and were consistent with the National Institute of Healths Guide for the Care and Use of Laboratory Animals