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(2020) suggest that Ca 2+ -dependent modulations appear to be concentrated in S2S3 (Zhao et al., 2020)

Given that the IC 100 concentration of niclosamide required to completely prevent viral replication in SARS-CoV-2 infected Calu-3 lung cells as measured by Ko et al (34) as 2M, a 20uM niclosamide solution nasal spray is 10x this IC 100