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MPLA stimulation elicited a robust increase in oxidative metabolism at 24 hours, with further enhancement observed at 3 days post-treatment ( Figures 4B, C )

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At the same time, acetyl coenzyme A converted by SCFAs can also generate palmitic acid through the action of the cytoplasmic enzyme system, and palmitic acid can be transferred to the mitochondria to promote the formation of triglycerides and be stored in adipose tissue (126)

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A study (Krainz et al., 2016) found that a compound targeting mitochondrial nitrogen oxide free radicals can effectively inhibit iron death in a variety of cells, suggesting that mitochondrial lipid peroxidation plays a key role in iron death