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Similarly, the population of HIV reservoir cells that constitutes the major barrier to a cure for AIDS is exquisitely redox sensitive and could be selectively targeted by Trx and GSH inhibitors

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Activated microglia flood the lesion with TNF-, which in turn drives endothelial RIP1/RIP3/MLKL activation, disrupts the BSCB and amplifies leukocyte infiltration

j l ) Representative whole dorsal striatal images of NPY immunofluorescence from Trkb Penk-WT control ( j ), Trkb Penk-KO mutant injected at 3 M with Gsto2 -shRNA ( k ) or scrambled-shRNA ( l ) in the striatum and analysed at 8 M

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