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doi: 10.1111/j.1440-1797.2012.01572.x 201

The second reduces the accumulation of AGEs in human tissues by catabolizing and removing the generated AGEs (61)

doi:10.1042/BCJ20160103 23 Nguyen TL, Durn RV

Unlike other amino acids, Met metabolism is intimately associated with malignant transformation

In MASLD, hepatocytes undergoing lipotoxic injury release exosomes enriched in miR-192

Additionally, a 2021 investigation showed that Metformin may help protect against macular degeneration in older adults, while a 2022 study suggested that Metformin may reduce the need for joint replacement