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Furthermore, CBD exhibits a complex interaction with iNOS activity, where it paradoxically promotes M1 characteristics through elevated iNOS levels while simultaneously demonstrating an overall anti-inflammatory effect through reduced TNF- secretion

doi:10.1128/CMR.00056-05 53

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Guareschi, S

The limited data available from clinical trials underline the huge number of gaps in the safety and efficacy of curcumin nanoformulations for therapeutic purposes