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The dysconnection hypothesis (2016)

Galluzzi L, Vitale I, Aaronson SA, et al

Bacteria that reside harmlessly on the skin can become lethal when introduced directly into the bloodstream, leading to systemic infections that can cause sepsis, an overwhelming body-wide response to infection, which is a medical emergency

Inhibition (that is, membrane hyperpolarization) in the adult CNS is mediated by Cl ions fluxes through several types of Cl channels and ionotropic GABA and glycine receptors