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First, future trials must embed formal health-economic evaluations rather than treating them as post-hoc add-ons

erinaceus has been recognized for its beneficial effects on digestive function [203]

SFN functions as an HDAC inhibitor in mammalian cells, leading to increased histone acetylation and re-expression of epigenetically silenced tumor suppressor genes (117)

Increases in lung prolyl hydroxylase and superoxide dismutase activities during bleomycin-induced lung fibrosis in hamsters

It is characterized by progressive skeletal muscle weakness, restrictive cardiomyopathy, and conduction blocks, often presenting in early adulthood

The efficacy depends on factors such as chemical composition, extraction method, and solvent used, with organic extracts showing greater activity than aqueous ones due to better solubility of active compounds [608]