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Interestingly, administering 2-AR blockers coupled with CAR-T would also prevent PKA-dependent inhibition of ZAP70 phosphorylation, thereby boosting T cell activation, co-stimulation, and cytotoxicity [123]

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Importantly, the observed oxidative damage and mitochondrial impairment following GCLC knockdown were reproduced across multiple assays and time points, reinforcing its critical role in redox regulation and cellular viability [31,32,33]

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Importantly, SSNHL can be reversible if treated promptly, making early intervention critical