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The 1.4% gallbladder complication rate in clinical trials was almost entirely concentrated among participants who went too low on fat

However, therapeutic doses for treating deficiency range from high-dose oral supplements (1,0002,000 g daily) to intramuscular injections of 1 mg, particularly for pernicious anaemia or malabsorption conditions

Be sure to get in touch with a doctor any time you feel unwanted discomfort or experience suspicious unexpected effects

Without medical supervision, adverse effects cannot be appropriately monitored or managed

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There's no pharmacological reason to space them by a specific number of hours, but separating them simplifies side effect attribution if any local reaction occurs