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Furthermore, as relatively large, lipophobic, polypeptide protein molecules, cytokines generally do not easily diffuse across an intact BBB and thus, circulating levels do not accurately reflect brain cytokine levels

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In contrast, t5A11 and t8G12 bound scK2SP(Xa) and tcK2SP(Xa) while they showed no binding toward scK4SP(Xa) and tcK4SP(Xa)