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It was first reported 20 years ago that systemic IGFs could cross the bloodbrain barrier (BBB), when labeled IGFs were infused into the common carotid arteries of adult rats, and they were later on detected in the choroid plexus, median eminence, brain arterioles, and parenchyma[64]

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2020), and levels of GSH and associated enzymes are lower in the blood of patients with MDD (Maes et al