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JAMA Neurol , (2017)

GPX4 loss causes excessive lipid peroxide buildup and Treg cell ferroptosis in response to T cell receptor (TCR)/CD28 co-stimulation (201)

doi: 10.1161/STROKEAHA.121.034578 96

doi: 10.1007/s00005-007-0006-x 123 MuniyanSChaturvediNKDwyerJGLaGrangeCAChaneyWGLinM-F

Mol Cell Endocrinol (2013) 369(1-2):1526

The skin is chronically exposed to both endogenous and environmental pro-oxidants leading to the production of ROS.[] ROS leads to lipid peroxidation, which is considered as the hallmark of oxidative stress in body.[] Malondialdehyde (MDA) is considered as the end product of lipid peroxidation and MDA levels is directly proportional to the oxidative stress.[] The most important antioxidants present in human body include superoxide dismutase, glutathione peroxidase, and catalase.[] Glutathione which is considered a master antioxidant can help keep the balance between the oxidant and antioxidant system in the body and prove to be an effective therapy but studies proving its efficacy are limited