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Disclosures: Yu Sato: Nothing to Disclose, Takahiro Kodama: Chugai Pharmaceuticals: Speaking and Teaching, Astrazeneca: Speaking and Teaching, Eisai Co Ltd: Speaking and Teaching, Yoshinobu Saito: Nothing to Disclose, Yuki Tahata: Nothing to Disclose, Kazuhiro Murai: Nothing to Disclose, Akira Doi: Nothing to Disclose, Kumiko Shirai: Nothing to Disclose, Kazuki Maesaka: Nothing to Disclose, Hayato Hikita: Nothing to Disclose, Tomohide Tatsumi: Nothing to Disclose, Tetsuo Takehara: Nothing to Disclose 706 THE DISTINCT EXPRESSION PATTERNS OF ENO1 IN MALIGNANT CELLS AND CD8+ T CELLS PLAY A CRUCIAL ROLE IN SHAPING THE "EVOLUTION TREE" OF HCC Jing He 1 Boqiang Liu 1 Liang Shi 1 Xiujun Cai 1 , 1 Zhejiang University Background Tumour evolution was influenced by cytokines, food metabolism, and cell-cell contact