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This gradual increase is essential to minimize gastrointestinal side effects and enhance patient tolerance

In the Phase 3 REDEFINE 1 trial, cagrilintide monotherapy achieved 11.8% average weight loss over 68 weekscomparable to semaglutide but with a notably lower incidence of nausea and vomiting, making it a potential option for patients who dont tolerate GLP-1 medications well

However, it did not have a significant effect on chromosomal fragility that was already present

In conclusion, OIFE demonstrated potent antioxidant and neuroprotective effects, successfully ameliorating D-galinduced memory deficits and neurogenesis impairments in rats

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