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HNF4, in cooperation with its target HNF1, directly inhibits transcription of the EMT master regulatory genes, Snail and Slug , repressing the mesenchymal program and EMT of hepatocytes (97)

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The molecular pathologic processes believed to occur in smallpox take a toll on GSH concentrations: (a) induction of iNOS with increased NO production, (b) the generation of superoxide, (c) formation of peroxynitrite, (d) GSH-consuming chain reactions of ROS and RNS, (e) TNFa related oxidative stress, the induction of Cox-2 with increased oxidation of arachidonic acid, (g) oxidative bursts from macrophages engaged in phagocytosis at sites of infection and inflammation, and related cascades