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This approach has led to one of the early programmes for inhaled insulin and eventually to FDA-approved inhaled l-DOPA for the treatment of Parkinson disease 106,107

The other three treatment groups were represented approximately equally in the largest cluster, with a maximum of one animal per treatment group outside the cluster

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In summary, RNK06138 is a potent, tumor-selective, and efficacious chaperone-mediated ERK5 degrader that could be used in tumor-targeted therapy