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Studies have shown that NCOA4 mediates the catabolism of ferritin according to the characteristics of the cellular environment, which regulates the mechanism of ferroptosis more significantly than directly inhibiting GPX4 to induce ferroptosis [97]

[Abstract]2025 Nov 20;8(1):1626

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NLRP3 inflammasome and inflammatory diseases

Imbalances in iron metabolism, especially iron overload, are important causes of ferroptosis

When used in combination, these compounds support exploration of convergent secretagogue signalling, receptor crosstalk, and dualpathway regulatory responses under controlled laboratory conditions