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3 Tissue-Specific Signaling Researchers frequently evaluate GHK-Cu for its potential role in: Neo-angiogenic signaling Extracellular matrix responses Fibroblast communication Collagen-related pathways The peptide-copper interaction often appears to influence multi-step cascades related to structural integrity and cellular turnover

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Two of these were at the NTD of CSP upstream of the repeat region while the third was at the junction between the repeat region and the C-terminal domain (CTD)

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Through cell scratch experiments, it was found out that the proliferation rate of SLC7A11 over-expression cells increased ( Figure 6E )

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