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Glutathione plays a variety of roles in the body, including: regenerating other antioxidants (e.g., vitamin C, vitamin E) neutralizing free radicals detoxification of certain drugs regulating the immune system managing inflammation supporting various bodily systems (e.g., nervous system, pulmonary system) delaying cell aging Glutathione depletion is also linked to numerous health issues, including increased susceptibility to infectious diseases and illnesses, oxidative stress, and certain chronic diseases, such as type 2 diabetes, certain types of cancer, kidney disease, neurodegenerative disease, liver disease, and cardiovascular disease ( 1 , 2 )

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Color figures are included in the HTML version of this manuscript Additional information Edited by A Finazzi-Agro Supplementary Information accompanies the paper on Cell Death and Differentiation website ( Supplementary information Rights and permissions About this article Cite this article Franco, R., Cidlowski, J

Plant Physiol 139:12911303 Pei ZM, Murata Y, Benning G, Thomine S, Klusener B, Allen GJ, Grill E, Schroeder JI (2000) Calcium channels activated by hydrogen peroxide mediate abscisic acid signalling in guard cells

Cytokine activation has been noted in ME/CFS patients (225) and appears to increase along with disease severity (231)

J Thorac Cardiovasc Surg 121(1):48-60, 2001