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44 The limited number of cases describing statin-induced cholestasis can be explained by its overlap with cholestatic DILI

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Interestingly, the NO donor S-nitroso N-acetylpenicillamine, the nonspecific NOS inhibitor NG-nitro-L-arginine methyl ester, and the specific nNOS inhibitor 1-(2-trifluoromethylphenyl) imidazole significantly reduce creatine kinase leakage, cell necrosis, and apoptosis in diabetic myocardium (Barua et al., The modulation of NO-mediated pathways through dietary supplementation with L-arginine or its precursor L-citrulline may represent an effective and practical strategy to prevent and treat MS, including obesity, T2DM, and dyslipidemia, in mammals such as humans (Jobgen et al., Pathways that regulate mitochondrial biogenesis have recently emerged as potential therapeutic targets for the amelioration of the endothelial and vascular dysfunction observed in metabolic diseases (Schulz et al., 2008)

Clinical correlates of increased plasma hypoxanthine include increased muscle activity and hypoxia (7679)