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Originally identified in bacteria, true SspA's present the characteristic GST fold but lacks GST binding activity due to replacement of the catalytic cystine residue (Hansen et al ., Reference Hansen, Gu, Li, Andrykovitch, Waugh, Jin and Ji2005)

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Laboratory studies use these receptor systems to investigate peptide mediated signaling pathways involved in neuroendocrine communication, nutrient sensing, and metabolic regulation within experimental models

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An increase in liver PPARgamma2 is an initial event to induce fatty liver in response to a diet high in butter: PPARgamma2 knockdown improves fatty liver induced by high-saturated fat