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Often brought on by extensive sun exposure and damage, pregnancy, hormone treatments, and hyperthyroidism, melasma is seen most often in women aged 20 to 40.Although it can occur in individuals of any nationality, this condition is most likely to affect Fitzpatrick skin types 3 and 4, or skin with a naturally-tanned appearance as seen in the Middle East and Asia

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More recent studies with the Romanian population suggest that the polymorphism of the Ile105Val gene was associated with the risk of developing type 2 DM, but not with the risk of developing DN

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Smoking marijuana, whether through joints or with devices like vapes or bongs, can irritate and damage the respiratory system