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During energetic stress, mTORC2 can also be activated by AMPK through phosphorylation of S1261 on mTOR [84, 85]

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When to seek urgent medical advice during treatment: Persistent or severe vomiting or diarrhoea preventing adequate fluid intake, or signs of dehydration (dizziness, reduced urine output, confusion) Signs of hypoglycaemia (shakiness, sweating, confusion, palpitations) Severe or persistent abdominal pain, which may rarely indicate pancreatitis Right upper quadrant pain, fever, or jaundice, which may suggest gallbladder disease New or worsening visual changes (particularly in people with pre-existing diabetic retinopathy, as rapid improvement in blood glucose control can occasionally affect the retina) Any new or worsening symptoms that concern you Your GP remains your first point of contact for any health concerns arising during participation in a clinical trial