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Combining glutamine-targeted treatments with oncogene inhibitors may create synthetic lethality

Detailed methods for transcriptome analysis are provided in the Supplementary Methods

Culturing HSCs in conditioned medium from M1 macrophages upregulated the expression of fibrosis-related genes (CTGF, TIMP1) and YAP-regulated genes (ANKRD1, CYR61)

The investigators followed the patients for 51 months

Therefore, it has been theorized that inhibition of xCT activities could promote Glu to replenish the TCA cycle intermediates, which could promote ROS production (102) ( Figure 4 )

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