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It is imperative to explore novel strategies aimed at reducing MMA levels, considering the limited efficacy of B12 supplementation revealed by our findings

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Cellular redox homeostasis depends on the balance between the generation and elimination of ROS by several enzymes and antioxidants, and the imbalance of cellular redox homeostasis leads to oxidative stress, which imposes a substantial burden on cells [29, 30]

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Additionally, another study demonstrated that AMPK is a negative switch of the Warburg effect in cell and animal models (160)